Journal article
Symptomatic intracranial hemorrhage after stroke thrombolysis: Comparison of prediction scores
D Strbian, P Michel, DJ Seiffge, JL Saver, H Numminen, A Meretoja, K Murao, B Weder, N Forss, AK Parkkila, A Eskandari, C Cordonnier, SM Davis, ST Engelter, T Tatlisumak
Stroke | LIPPINCOTT WILLIAMS & WILKINS | Published : 2014
Abstract
Background and Purpose-Several prognostic scores have been developed to predict the risk of symptomatic intracranial hemorrhage (sICH) after ischemic stroke thrombolysis. We compared the performance of these scores in a multicenter cohort. Methods-We merged prospectively collected data of patients with consecutive ischemic stroke who received intravenous thrombolysis in 7 stroke centers. We identified and evaluated 6 scores that can provide an estimate of the risk of sICH in hyperacute settings: MSS (Multicenter Stroke Survey) HAT (Hemorrhage After Thrombolysis) SEDAN (blood sugar, early infarct signs, [hyper]dense cerebral artery sign, age, NIH Stroke Scale) GRASPS (glucose at presentation,..
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Awarded by Swiss National Science Foundation
Awarded by Australian National Health and Medical Research Council Centre for Research Excellence grant
Awarded by Swiss National Science Foundation (SNF)
Funding Acknowledgements
This study was supported by the Helsinki University Central Hospital (HUCH) governmental subsidiary (EVO) funds for clinical research. The authors received funding from the HUCH (D. S., A. M., T. T.), the Biomedicum Helsinki Foundation (A. M.), the Sigrid Juselius Foundation (A. M., T. T.), the Finnish Medical Foundation (A. M.), the Stroke-[Hirnschlag]-Fund Basel (D.J.S.), the Swiss National Science Foundation No. 33CM30-124119 (S. T. E.), and Australian National Health and Medical Research Council Centre for Research Excellence grant 1001216 (A. M., S. M. D.). The supporting sources had no involvement in the design, analyses, or interpretation of the study.